Valsartan Pathway Map

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This pathway was contributed by Debora Käer, Eawag.

Valsartan is a pharmaceutical used for hypertension treatment. It is a second class of angiotensin II receptor antagonist (Biswas et al., 2010).

In laboratory batch experiments with activated sludge from a membrane bioreactor, the main transformation products observed were the products of enzymatic dealkylation, subsequent enzymatic hydrolysis and oxidative deamination of the resulting amine to yield valsartan acid (Helbling et al., 2010). The transformation products found in the membrane bioreactor were also found to be formed in sludge from conventional activated sludge treatment. Valsartan acid was found to be mostly stable under these conditions (Kern et al., 2010).

The following is a text-format valsartan map. Mixed bacterial cultures from activated sludge treatment can initiate the pathway. Follow the links for more information on compounds or reactions. This map is also available in graphic (4k) format.

 
			Valsartan
        	   Aerobic mixed culture
              from activated sludge treatment 
                 	    |
                 	    | valsartan                          
                 	    | oxidoreductase 
                 	    |
                 	    v
                 Dealkylated valsartan
			    |
 			    | dealkylated valsartan
			    | hydrolase
			    |
			    v
	            Amino-valsartan
			    |
			    | amino-valsartan
			    | oxidoreductase
			    |
			    v
    [2'-(1H-tetrazol-5-yl)biphenyl-4-yl]acetaldehyde
			    |
			    | [2'-(1H-tetrazol-5-yl)biphenyl-4-yl]acetaldehyde
			    | oxidoreductase
			    |
			    v
	   	      Valsartan acid

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Page Author(s): Debora Käser

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http://eawag-bbd.ethz.ch/vas/vas_map.html