Rule bt0364

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Pattern 2870
Pyridine -> 5-Iminopentanoate


Aerobic Likelihood:              Neutral

EAWAG-BBD Reaction(s):
Not found

Comments:
This rule handles the unsubstituted pyridine ring cleavage pathway. An initial reduction step breaks aromaticity of the ring, forming a 1,4-dihydropyridine intermediate which is predicted to undergo hydrolytic cleavage to produce 5-iminopentaldehyde (Watson and Cain, 1975). The aldehyde is quickly oxidized to form 5-iminopentanoate (bt0003). The iminoaldehyde is postulated to transition between the linear form and a cyclic tautomer (see graphic). This rule does not handle the tautomerization.


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Page Author(s): Michael Turnbull
December 01, 2009

This is the EAWAG-BBD biotransformation rule, ruleID# bt0364.
It was generated on April 19, 2024 4:14:24 PM CDT. 

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