Phenylacetaldoxime is an intermediate in the biosynthesis of benzylglucosinolate. It is a glucosinolate and this class of natural products are gaining increasing interest as cancer-preventing agents and crop protectants.
The first enzyme in its biodegradation pathway, phenylacetaldoxime dehydratase, is interesting not only because it can degrade phenylaldoxime to phenylactonitrile, but also because of its potential in organic synthesis since the chemical dehydration of aldoximes usually requires harsh reaction conditions (Kato et al., 1998). The degradation pathway of phenylacetonitrile shown here is similar to the Benzonitrile Pathway.
The following is a text-format Z-phenylacetaldoxime pathway map. An organism which can initiate the pathway is given, but other organisms may also carry out later steps. Follow the links for more information on compounds or reactions. This map is also available in graphic (8k) format.
Z-Phenylacetaldoxime Bacillus sp. strain OxB-1 | | | phenylacetaldoxime | dehydratase | v +-----Phenylacetonitrile-----+ | | | | | | | | nitrile hydratase | | nitrilase | | | v | Phenylacetamide | | | | | | amidase | | v | Phenylacetate <--------------------+ | | | | v to the Phenylacetate Pathway
Page Author(s): Wenjun Kang
October 10, 2011 BBDMaster@mail.ahc.umn.edu
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