Oseltamivir Pathway Map

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This pathway was contributed by Debora Käser, Eawag.

Oseltamivir is an antiviral drug which is used to treat flu symptoms. It is marketed asTamiflu in the form of oseltamivir phophate. In human body, oseltamivir phosphate is metabolized to its active metabolite oseltamivir carboxylate, which then inhibits influenza A and B neuraminidases (Vishkaee et al., 2013).

In laboratory batch experiments with activated sludge from a membrane bioreactor, the main transformation product observed was the product of carboxylic acid, i.e. oseltamivir carboxylate (Helbling et al., 2010). Oseltamivir carboxylate was observed to be further degraded in mixed communities from water, sediment and wastewater. Two bacterial strains could be isolated from water and wastewater that used Oseltamivir carboxylate as sole carbon and energy sources. Natural communities amended with these strains showed increased mineralization potential (Accinelli et al., 2013).

The following is a text-format oseltamivir map. Mixed bacterial cultures from activated sludge treatment can initiate the pathway. Follow the links for more information on compounds or reactions. This map is also available in graphic (3k) format.

                       Oseltamivir
        	  Aerobic mixed culture
              from activated sludge treatment
                 	    |
                 	    | oseltamivir                          
                 	    | hydrolase 
                 	    |
                 	    v
 	         Oseltamivir carboxylate
			    |
			    |
			    |
			    v
			    | 
			    |
			    |
			    v
 	         Carbon Dioxide + Water

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Page Author(s): Debora Käser

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